Genes, HPV and Cervical Cancer – Research by Dr. Margaret Madeleine and colleagues found that
certain gene variants may lead to the development of cervical cancer in women with HPV infection. By analyzing immune-system genes — known as human leukocyte antigen (HLA) genes — of women with and without cervical cancer, researchers found evidence that certain gene variants may affect women's cancer risk. The discovery may help explain why only a small proportion of women infected with the cancer-causing form of HPV develop cervical cancer and ultimately aid scientists as they continue to develop cancer treatments in women already infected with HPV. Learn more »
Detection & Diagnosis
Increasing screening in ethnic communities – Hispanic women have about twice the risk of developing invasive cervical cancer as non-Hispanic women, and Hispanic women are less likely to get regular Pap tests. Research by Dr. Carol Moinpour and colleagues has suggested that Hispanic female cancer survivors who are trained as lay health educators can successfully increase cancer-screening rates among their network of family members and friends. Learn more »Vietnamese women have higher rates of cervical cancer than any other racial or ethnic group (including Hispanics), according to cancer-registry data. Surveys of Seattle-area Vietnamese-American women led by Drs. Vicky Taylor, Stephen Schwartz and colleagues have shed some light on the cultural beliefs that may explain why such women tend not to be screened regularly. Learn more »
Treatment & Prognosis
Predicting mortality – Dr. Stephen Schwartz and colleagues observed that a strain of human papillomavirus called HPV 18, found in up to 30 percent of women with cervical cancer, appears to be associated with a mortality rate nearly double that of other HPV-related cervical cancers. Results of the research confirm several previous smaller studies that suggest HPV 18 may be an excellent indicator, or biomarker, for predicting outcomes for women diagnosed with early-stage cervical cancer. Learn more »Source : http://www.fhcrc.org
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