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Boceprevir approved for use by Britain's state health service.

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Merck’s new hepatitis C drug, Boceprevir (Victrelis) has won recommendation for use in Britain’s state health service. It was widely discussed especially because the drug is especially expensive. This an important drug because unlike previous INV +Ribavirin combination therapy, Boceprevir can be used in the treatment of hepatitis due to HCV genotype 1, the most common form of hepatitis C. It will be used in combination with Pegylated Interferon and Ribavirin for genotype 1 hepatitis C.

Boceprevir is an NS3/4A protease inhibitor. This drug stops viral replication by binding to a protease that would work to cleave the polyprotein. Thus this drug prevents the production of functional viral protein. Pegylated interferons are used to moderate the immune system. Ribivirin is a nucleoside analog and when given with IFN, it can reduce viral replication.

Original Article from Reuters: http://www.reuters.com/article/2012/03/09/merck-britain-idUSL5E8E8AH120120309

More info on HCV Medications:
http://emedicine.medscape.com/article/177792-medication#2

--Elena Jordan

We're hard at work!

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This weekend, we had our quaterly meeting at the Peace Corps Office in Kigali, the capitol of Rwanda and most beautiful and cleanest city on the continent of Africa.
_______________________________________________________

Past Successes:*Creating the committee and writing the by laws*The GAD Blog and regular SOMA contributions*Having GAD represented at all Peace Corps trainings and writing lesson plans for each training *Creating the GLOW/BE Committee to support GLOW/BE Camps*Creating the GLOW/BE VAST Grant Workbook*Conducting and analyzing the results of the all volunteer GAD survey*Coordinating the field testing of the translated Life Skills Manual
Current Projects:*Creating a GAD Manual focused on project ideas for adults*Forging a partnership between Peace Corps and Ni Nyampinga magazine*Promoting and updating the GAD blog*Collecting stories from volunteers to make senior staff aware of the prevalence of sexual harassment*Working with PSN to support volunteer who experience sexual harassment by designing a yearly retreat
Future Project Ideas:*Working with PC GAD committees in other countries to create an international PC GAD forum*Making GAD resources more accessible to volunteers through an online forum*Creating ways to help volunteers celebrate International Women's Day in their communities*Creating discussion questions for volunteers to discuss monthly at their regional meetings.  Encouraging inter-regional dialogues once or twice a year to discuss GAD related issues.

mackenzie's eyes are naturally that piercing (L to R: Alma, Lucy, Mackenzie, Chinelo, Gelsey)

resident jokesters (Zach and Chinelo)

awkward candid (L to R: Zach, Joel, Tashiya, Hope, Sarah D, Sarah E.)

all good! 

pamela's happy face, very happy face :)

Gelsey gets down to business

we are serious (L to R: Joel, Pamela, Tashiya)

What's a Nun Got to do With it? by Tashiya G.

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Tashiya Gunesekera
ED2 -- Rubavu District, Western Province


My first friend in myvillage was a nun. Her name was Eleonora, a primary school teacher.She came to visit me in my temporary housing and commented that Ineeded to clean my floors more often. I felt, knowing what I knew ofRwandan culture, that she was going to be a genuine friend.
I live in small town inthe Northwest of Rwanda. I am very connected to the Catholic church,which predominates my town. I eat all my meals with the priests, andtake myself up the hill to Sunday mass every Sunday I'm at site. Thenuns live in a quaint house connected to the health clinic in town,which they run. There are two nuns from Spain named Aurelia and MariaJesus who are there as mentors and teachers for the Rwandan Nuns whowere Eleonora, Matilde, Marcelline, and Vestine. We quickly becamefriends due to the shortbread-like cookies they gave me every time Icame to visit at 530pm any weekday. As they said recently, “Tashiya,sabemos que te gusta las dolces.” (Tashiya we know that youlike the sweets.)
Throughout my time atsite, I have spent time getting to know the nuns. They helped me thattime I had a bad day and could not find any Margarine to make Mac andCheese. They listened to me complaining about all the papers I had tomark. They invited me to watch Spain trounce Italy in the Euro Cupthis year. They gave me a thermometer when I thought I was sick. Andmost importantly they helped me with my book project to get moreEnglish reading books for my school library. These books were sent totheir mailbox in Gisenyi and they carted them up the steep mountainin their car. During this time, I've had multiple opportunities toanalyze their lives.
Not being Catholic,apart from the “Sister Act”, I personally did not know much aboutnuns before I moved to this small town in Rwanda. I thought nuns weresuper religious women that gave up a life of family and love toworship God and help poor people. And, yes in some ways this is true.They do give up having a traditional family and romantic love, andthey are religious and they do help poor people. But, there is a lotmore to these nuns than that.
The nuns at my site allhave serious jobs and careers in the making. Eleonora was a primaryschool teacher, Vestine was a nurse at the health clinic, Marcellinetrains girls that are not in school in trades like sewing, andcooking, and Matilde was responsible for teaching young mothers aboutnutrition. The two Spanish nuns oversaw much of the running of theclinic and also were responsible for the running of their home.
Within my community,these nuns are considered to be influential people. They are often atsector, cell and village events. They sit with the important peoplewho thank goodness, I have finally been cleared of sitting with. (I'mfinally one with the people!) They also live in a nice house and haveaccess to a car to go to the nearest big town, Gisenyi andoccasionally Kigali. These nuns, probably due to their congregation,have serious opportunities to travel. Eleonora broke my heart whenshe said in the beginning of the second year that she was leaving togo live in Equatorial Guinea for her next mission. Mathilde moved onto the Ivory Coast. Vestine went to University in Kigali. Thisbrought in two new Nuns, Immaculee and Larisse. Immaculee is also anurse with a degree from a University in Kigali. She speaks fluentFrench, English and Spanish. Larisse is from the Democratic Republicof the Congo. Larisse is awaiting her time before she also wants tomove on to the Ivory Coast. I know that Eleonora spent two months inSpain visiting more Nuns from her order.
Many of these womencome from very poor families. Their choice to become a Nun obviouslychanged their lives. But, they are very strong women who are greatlyrespected and honored within Rwanda. They gain high levels withintheir professional fields and are supposed and encouraged withintheir communities. Even though they are not the head of the communitychurch like a Priest, they are still leaders and contributing greatlyto the societies in where they live. Do I think that all girls shouldaim to become Nuns? Not unless you get that calling because it isafter all a life where you give up a lot of comforts. But, it'sworth noticing how in a quiet way, Nuns are contributing to bridgingthe gender divide in rural communities and encouraging women tosucceed.

International Girls' Day Essay Competition Winners by Sarah D.

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Sarah DoyleEd2 - Kigali City
For International Girls' Day on October 11th, PCVs teamed up with Girl Hub, part of the Nike Foundation, to do an essay competition at some of our schools. The winners for both Kinyarwanda and English were sent along to me to select a few to go into Girl Hub's magazine, Ni Nyampinga. The magazine LOVED the essays and will be publishing excerpts from them all in the coming issue, but I thought this would be a good forum to post the English essays in their entirety. The question that we posed to the students was: "Why do you value yourself and what can you do to help develop your community?" Very often our students struggle with critical thinking, but I'm sure you'll agree, the essays below are very powerful and speak to the growing determination of young girls in Rwanda to not only study and create a future for themselves, but also to help their communities.
So now for the winners...
KABASINGA Flaviah,S6HEG, 18 years oldCollege De Rushaki,Gicumbi District, Northern ProvincePCV: Lucy Sung
Why do I value myselfand What can I do for my community?Value is somethinginside which makes one to be more important and to be useful. One can be valuedaccording to how one values herself in the society or among other people. I value myself in order to gain self respectamong others and this self respect cannot be given to me when I have not knownthe value I have. When one values herself, it will make her gain responsibilityin the community because everyone believes that she has knowledge and she iscapable of doing everything for the society. I value myself so thatI can uplift and restore the traditional culture of our community becauseculture makes all the people in the society to be unite and respective of eachother.When I value myself, Igain confidence and hope in myself to work and develop my community in order toachieve development and prosperity to the nation. The value I give to myselfmakes it easier for to plan for my future because when I get to know the valueI have, I don’t let it down but I fight to make it better even for people tohonour me. I value myself becauseam a co-creator of God so I have to make sure that God has more value thaneverything and I have to value myself so that God can be happy with me throughshowing good examples to other creatures.I value myself becauseam a coordinator of all living things in the world .I have the power andsupremacy to control and manage everything in the world.Value brings hope,peace, and love in the society that is why I value myself because when Irespect others they also respect me, which makes us equal ad makes me morevaluable.Value brings harmonyin the society because when I value myself and others, I give a good example toothers which makes the society to live happily.All I can do for mycommunity is to keep the value of our society is to respect each other andencourage them to have love, patience, and courage in what they do. For mycommunity, I can encourage them to have the spirit of the traditional cultureand nationalism in order to keep stability in the society. Encouraging people tohave confidence and to work hard in order to achieve development which canvalue our community. I can help my community to teach them what value is, whythey need it, and how they can achieve it, because value makes people to knowntheir human rights._________________________________________________________________
UWIMBABAZI Gemime, Senior 6 MCBE.S. BUGARAMA, Rusizi District, Western ProvincPCV: Jeff Monsma
I know I have value because:- I’m able to teach other girls.- I’m able to be and I will become a good leader.- I’m able to advise others.- I have the chance to study, while before girls didn’t getthat chance.- I have my self-esteem!- I know how to prevent AIDS.- I am able to fight against peer pressure.- I have the power to change the world.- I am able to create friendship between students.- I behave well- I am able to run the world, teaching women and girls abouthow theycan have self esteem, how they can fight peer pressure, andso on. AndI’ll do it because everything is possible!

C9ORF72 Repeat Expansions in the Frontotemp... [J Alzheimers Dis. 2012] - PubMed - NCBI

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C9ORF72 Repeat Expansions in the Frontotemp... [J Alzheimers Dis. 2012] - PubMed - NCBI

J Alzheimers Dis. 2012 Dec 19. [Epub ahead of print]

C9ORF72 Repeat Expansions in the Frontotemporal Dementias Spectrum of Diseases: A Flowchart for Genetic Testing.

Le Ber I, Camuzat A, Guillot-Noel L, Hannequin D, Lacomblez L, Golfier V, Puel M, Martinaud O, Deramecourt V, Rivaud-Pechoux S, Millecamps S, Vercelletto M, Couratier P, Sellal F, Pasquier F, Salachas F, Thomas-Antérion C, Didic M, Pariente J, Seilhean D, Ruberg M, Wargon I, Blanc F, Camu W, Michel BF, Berger E, Sauvée M, Thauvin-Robinet C, Mondon K, Tournier-Lasserve E, Goizet C, Fleury M, Viennet G, Verpillat P, Meininger V, Duyckaerts C, Dubois B, Brice A.

Source

CRicm-UMRS975, Paris, France AP-HP, Hôpital de la Pitié-Salpêtrière, Centre de Référence des Démences Rares, Paris, France AP-HP, Hôpital de la Pitié-Salpêtrière, Fédération des maladies du système nerveux, Paris, France.

Abstract

Frontotemporal dementia (FTD) refers to a disease spectrum including the behavioral variant FTD (bvFTD), primary progressive aphasia (PPA), progressive supranuclear palsy/corticobasal degeneration syndrome (PSP/CBDS), and FTD with amyotrophic lateral sclerosis (FTD-ALS). A GGGGCC expansion in C9ORF72 is a major cause of FTD and ALS. C9ORF72 was analyzed in 833 bvFTD, FTD-ALS, PPA, and PSP/CBDS probands; 202 patients from 151 families carried an expansion. C9ORF72 expansions were much more frequent in the large subgroup of patients with familial FTD-ALS (65.9%) than in those with pure FTD (12.8%); they were even more frequent than in familial pure ALS, according to estimated frequencies in the literature (23-50%). The frequency of carriers in non-familial FTD-ALS (12.7%) indicates that C9ORF72 should be analyzed even when family history is negative. Mutations were detected in 6.8% of PPA patients, and in 3.2% of patients with a clinical phenotype of PSP, thus enlarging the phenotype spectrum of C9ORF72. Onset was later in C9ORF72 (57.4 years, 95%CI: 55.9-56.1) than in MAPT patients (46.8, 95%CI: 43.0-50.6; p = 0.00001) and the same as in PGRN patients (59.6 years; 95%CI: 57.6-61.7; p = 0.4). ALS was more frequent in C9ORF72 than in MAPT and PGRN patients; onset before age 50 and parkinsonism were indicative of MAPT mutations, whereas hallucinations were indicative of PGRN mutations; prioritization of genetic testing is thus possible. Penetrance was age- and gender-dependent: by age 50, 78% of male carriers were symptomatic, but only 52% of females. This can also guide genetic testing and counseling. A flowchart for genetic testing is thus proposed.

PMID:

23254636

[PubMed - as supplied by publisher]

A centralized approach to out-of-province genetic... [Clin Genet. 2012] - PubMed - NCBI

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A centralized approach to out-of-province genetic... [Clin Genet. 2012] - PubMed - NCBI

Clin Genet. 2012 Dec 17. doi: 10.1111/cge.12077. [Epub ahead of print]

A centralized approach to out-of-province genetic testing leads to cost savings: The Alberta Experience.

Lilley M, Christian S, Blumenschein P, Chan S, Somerville M.

Source

Genetic Laboratory Services, Alberta Health Services, 8-26 Medical Sciences Building, University of Alberta, Edmonton, Alberta, CANADA, T6B 0K9. Margaret.Lilley@albertahealthservices.ca.

Abstract

The Genetic Resource Centre is a centralized process for requesting genetic testing that is not available within the province (Alberta, Canada). In order to assess potential cost savings associated with this process, all applications received by the Genetic Resource Centre in 2010 were reviewed, and cost savings were recorded for statistical analysis. Seven areas of cost savings were identified:Negotiated pricing;Laboratory selection;Testing set up in province;Duplicate testing;Inappropriate testing;Sequential testing and;Testing offered within the province. The total test cost of the 615 applications submitted in 2010 without the GRC process would have been $766 783 (Canadian dollars). A total cost savings of $112 201 was achieved through the GRC, which represents 15% of the total cost of requested testing ($112 201/$766 783). This is the first study to examine areas of cost savings for genetic testing sent out -of-province. The greatest cost savings resulted from the areas of laboratory selection and negotiated pricing. A centralized process to manage out-of-province genetic test requests results in consistency in testing and significant cost savings.
© 2012 John Wiley & Sons A/S.

PMID:

23252955

[PubMed - as supplied by publisher]